IV Ketamine Therapy For Depression | San Francisco Bay Area | West PortalWavemaker2021-01-29T23:35:34+00:00
IV Ketamine Therapies for Depression, Anxiety and PTSD
San Francisco Preventive Medical Group provides leading edge IV Ketamine Therapy for rapid resolution of depression, anxiety, PTSD and nerve pain, such as Complex Regional Pain Syndrome (CRPS). Ketamine, a drug that blocks pain, was developed in the 1960s for use in surgeries. In 2000, researchers discovered that it was also effective for treating depression, even when other treatments failed. Ketamine treatment focuses on repairing the damage inflicted upon the brain from cortisol and other stress hormones that build up from extended bouts of depression. Ketamine won FDA approval for the rapid treatment of depression in 2019. It is currently under review by the FDA to be approved for the treatment of PTSD
What does it do?
Ketamine increases neural connectivity and neuroplasticity by affecting multiple receptors and pathways in the brain and body. One of the key pathways it affects is the amino acid, glutamate, pathway. Glutamate plays a central role in both the normal and abnormal functioning of the central nervous system, and a growing body of evidence points to the role of glutamate in mediating the brain’s response to stress and the formation of traumatic memories. Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist, so it binds to the NMDA receptor protein and blocks glutamate from attaching to cell membranes.
An increasing level of N-methyl-D-aspartate (NMDA) receptor hypofunction within the brain is associated with memory and learning impairments, with psychosis, and with excitotoxic brain injury. Ketamine blocks at the NmethylDaspartate (NMDA) site and has rapid action in controlling symptoms of depression. Ketamine also acts on the mTOR pathway (a central regulator of metabolism and physiology), the AMPA receptor (which mediates fast synaptic transmission in the central nervous system) and the brain’s opioid receptors (which control pain, reward and addictive behavior).
Research has shown that, unlike antidepressant medications which typically require several weeks to take effect, ketamine can be rapidly effective, in a few days or even hours. Ketamine can have long lasting effects. Most people require multiple treatments.